A Broad Range of Mutations in HIV-1 Neutralizing Human Monoclonal Antibodies Specific for V2, V3, and the CD4 Binding Site

The HIV vaccine-induced neutralizing antibodies (Abs) display low rates of mutation in their variable regions. To determine the range of neutralization mediated by similar human monoclonal Abs (mAbs) but derived from unselected chronically HIV-1 infected subjects, we tested a panel of 66 mAbs specif...

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Publicat a:Mol Immunol
Autors principals: Li, Liuzhe, Wang, Xiao-Hong, Williams, Constance, Volsky, Barbara, Steczko, Olivia, Seaman, Michael S., Luthra, Kalpana, Nyambi, Phillipe, Nadas, Arthur, Giudicelli, Véronique, Lefranc, Marie-Paule, Zolla-Pazner, Susan, Gorny, Miroslaw K.
Format: Artigo
Idioma:Inglês
Publicat: 2015
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4461508/
https://ncbi.nlm.nih.gov/pubmed/25965315
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molimm.2015.04.011
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