A Broad Range of Mutations in HIV-1 Neutralizing Human Monoclonal Antibodies Specific for V2, V3, and the CD4 Binding Site

The HIV vaccine-induced neutralizing antibodies (Abs) display low rates of mutation in their variable regions. To determine the range of neutralization mediated by similar human monoclonal Abs (mAbs) but derived from unselected chronically HIV-1 infected subjects, we tested a panel of 66 mAbs specif...

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Gepubliceerd in:Mol Immunol
Hoofdauteurs: Li, Liuzhe, Wang, Xiao-Hong, Williams, Constance, Volsky, Barbara, Steczko, Olivia, Seaman, Michael S., Luthra, Kalpana, Nyambi, Phillipe, Nadas, Arthur, Giudicelli, Véronique, Lefranc, Marie-Paule, Zolla-Pazner, Susan, Gorny, Miroslaw K.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2015
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4461508/
https://ncbi.nlm.nih.gov/pubmed/25965315
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molimm.2015.04.011
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