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Mucosal Vaccination by Adenoviruses Displaying Reovirus Sigma 1
We previously developed adenovirus serotype 5 (Ad5) vectors displaying the sigma 1 protein from reovirus as mucosal vaccines. Ad5-sigma retargets to JAM-1 and sialic acid, but had 40-fold reduced gene delivery when compared to Ad5. While weaker at transduction, Ad5-sigma generated stronger T cell re...
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| Publicado no: | Virology |
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| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4461457/ https://ncbi.nlm.nih.gov/pubmed/25827529 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2015.02.050 |
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