CAG repeat lengths ≥335 attenuate the phenotype in the R6/2 Huntington’s disease transgenic mouse

With spontaneous elongation of the CAG repeat in the R6/2 transgene to ≥335, resulting in a transgene protein too large for passive entry into nuclei via the nuclear pore, we observed an abrupt increase in lifespan to >20 weeks, compared to the 12 weeks common in R6/2 mice with 150 repeats. In th...

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Udgivet i:Neurobiol Dis
Main Authors: Dragatsis, I., Goldowitz, D., Del Mar, N., Deng, Y.P., Meade, C.A., Liu, Li, Sun, Z., Dietrich, P., Yue, J., Reiner, A.
Format: Artigo
Sprog:Inglês
Udgivet: 2008
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4461140/
https://ncbi.nlm.nih.gov/pubmed/19027857
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2008.10.009
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