Design of a "minimAl" homeodomain: the N-terminal arm modulates DNA binding affinity and stabilizes homeodomain structure.

This report investigates the sequence specificity requirements for homeodomain structure and DNA binding activity by the design and synthesis of a "minimAl" homeodomain (for minimalist design and alanine scanning mutagenesis) which contains the consensus residues and in which all nonconsen...

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Hauptverfasser: Shang, Z, Isaac, V E, Li, H, Patel, L, Catron, K M, Curran, T, Montelione, G T, Abate, C
Format: Artigo
Sprache:Inglês
Veröffentlicht: 1994
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC44608/
https://ncbi.nlm.nih.gov/pubmed/7915838
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