Design of a "minimAl" homeodomain: the N-terminal arm modulates DNA binding affinity and stabilizes homeodomain structure.

This report investigates the sequence specificity requirements for homeodomain structure and DNA binding activity by the design and synthesis of a "minimAl" homeodomain (for minimalist design and alanine scanning mutagenesis) which contains the consensus residues and in which all nonconsensus residu...

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Pubblicato in:	Proc Natl Acad Sci U S A
Autori principali:	Shang, Z, Isaac, V E, Li, H, Patel, L, Catron, K M, Curran, T, Montelione, G T, Abate, C
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	National Academy of Sciences 1994
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC44608/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7915838/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.91.18.8373
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