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Integrative epigenomic and genomic filtering for methylation markers in hepatocellular carcinomas

BACKGROUND: Epigenome-wide studies in hepatocellular carcinoma (HCC) have identified numerous genes with aberrant DNA methylation. However, methods for triaging functional candidate genes as useful biomarkers for epidemiological study have not yet been developed. METHODS: We conducted targeted next-...

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Pubblicato in:BMC Med Genomics
Autori principali: Shen, Jing, LeFave, Clare, Sirosh, Iryna, Siegel, Abby B., Tycko, Benjamin, Santella, Regina M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2015
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4460673/
https://ncbi.nlm.nih.gov/pubmed/26059414
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12920-015-0105-1
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