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Integrative epigenomic and genomic filtering for methylation markers in hepatocellular carcinomas

BACKGROUND: Epigenome-wide studies in hepatocellular carcinoma (HCC) have identified numerous genes with aberrant DNA methylation. However, methods for triaging functional candidate genes as useful biomarkers for epidemiological study have not yet been developed. METHODS: We conducted targeted next-...

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Detalhes bibliográficos
Publicado no:BMC Med Genomics
Main Authors: Shen, Jing, LeFave, Clare, Sirosh, Iryna, Siegel, Abby B., Tycko, Benjamin, Santella, Regina M.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2015
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4460673/
https://ncbi.nlm.nih.gov/pubmed/26059414
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12920-015-0105-1
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