Alternative splicing converts STIM2 from an activator to an inhibitor of store-operated calcium channels

Store-operated calcium entry (SOCE) regulates a wide variety of essential cellular functions. SOCE is mediated by STIM1 and STIM2, which sense depletion of ER Ca(2+) stores and activate Orai channels in the plasma membrane. Although the amplitude and dynamics of SOCE are considered important determi...

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發表在:J Cell Biol
Main Authors: Rana, Anshul, Yen, Michelle, Sadaghiani, Amir Masoud, Malmersjö, Seth, Park, Chan Young, Dolmetsch, Ricardo E., Lewis, Richard S.
格式: Artigo
語言:Inglês
出版: The Rockefeller University Press 2015
主題:
Research Articles
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4460148/
https://ncbi.nlm.nih.gov/pubmed/26033257
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201412060
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