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The Toxic Effects of Pathogenic Ataxin-3 Variants in a Yeast Cellular Model
Ataxin-3 (AT3) is a deubiquitinating enzyme that triggers an inherited neurodegenerative disorder, spinocerebellar ataxia type 3, when its polyglutamine (polyQ) stretch close to the C-terminus exceeds a critical length. AT3 variants carrying the expanded polyQ are prone to associate with each other...
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| Pubblicato in: | PLoS One |
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| Autori principali: | , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Public Library of Science
2015
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4460139/ https://ncbi.nlm.nih.gov/pubmed/26052945 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0129727 |
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