A Major Role for Side-Chain Polyglutamine Hydrogen Bonding in Irreversible Ataxin-3 Aggregation

The protein ataxin-3 consists of an N-terminal globular Josephin domain (JD) and an unstructured C-terminal region containing a stretch of consecutive glutamines that triggers the neurodegenerative disorder spinocerebellar ataxia type 3, when it is expanded beyond a critical threshold. The disease r...

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Hauptverfasser: Natalello, Antonino, Frana, Anna Maria, Relini, Annalisa, Apicella, Alessandra, Invernizzi, Gaetano, Casari, Carlo, Gliozzi, Alessandra, Doglia, Silvia Maria, Tortora, Paolo, Regonesi, Maria Elena
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2011
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3076451/
https://ncbi.nlm.nih.gov/pubmed/21533208
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0018789
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