A Hydrophobic Gold Surface Triggers Misfolding and Aggregation of the Amyloidogenic Josephin Domain in Monomeric Form, While Leaving the Oligomers Unaffected

Protein misfolding and aggregation in intracellular and extracellular spaces is regarded as a main marker of the presence of degenerative disorders such as amyloidoses. To elucidate the mechanisms of protein misfolding, the interaction of proteins with inorganic surfaces is of particular relevance,...

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Main Authors: Apicella, Alessandra, Soncini, Monica, Deriu, Marco Agostino, Natalello, Antonino, Bonanomi, Marcella, Dellasega, David, Tortora, Paolo, Regonesi, Maria Elena, Casari, Carlo Spartaco
Format: Artigo
Language:Inglês
Published: Public Library of Science 2013
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3602447/
https://ncbi.nlm.nih.gov/pubmed/23527026
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0058794
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