A Hydrophobic Gold Surface Triggers Misfolding and Aggregation of the Amyloidogenic Josephin Domain in Monomeric Form, While Leaving the Oligomers Unaffected

Protein misfolding and aggregation in intracellular and extracellular spaces is regarded as a main marker of the presence of degenerative disorders such as amyloidoses. To elucidate the mechanisms of protein misfolding, the interaction of proteins with inorganic surfaces is of particular relevance,...

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Main Authors: Apicella, Alessandra, Soncini, Monica, Deriu, Marco Agostino, Natalello, Antonino, Bonanomi, Marcella, Dellasega, David, Tortora, Paolo, Regonesi, Maria Elena, Casari, Carlo Spartaco
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3602447/
https://ncbi.nlm.nih.gov/pubmed/23527026
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0058794
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