The Toxic Effects of Pathogenic Ataxin-3 Variants in a Yeast Cellular Model

Ataxin-3 (AT3) is a deubiquitinating enzyme that triggers an inherited neurodegenerative disorder, spinocerebellar ataxia type 3, when its polyglutamine (polyQ) stretch close to the C-terminus exceeds a critical length. AT3 variants carrying the expanded polyQ are prone to associate with each other...

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Veröffentlicht in:PLoS One
Hauptverfasser: Bonanomi, Marcella, Visentin, Cristina, Invernizzi, Gaetano, Tortora, Paolo, Regonesi, Maria Elena
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2015
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4460139/
https://ncbi.nlm.nih.gov/pubmed/26052945
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0129727
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