Induction of Neuron-Specific Degradation of Coenzyme A Models Pantothenate Kinase-Associated Neurodegeneration by Reducing Motor Coordination in Mice

BACKGROUND: Pantothenate kinase-associated neurodegeneration, PKAN, is an inherited disorder characterized by progressive impairment in motor coordination and caused by mutations in PANK2, a human gene that encodes one of four pantothenate kinase (PanK) isoforms. PanK initiates the synthesis of coen...

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Udgivet i:PLoS One
Main Authors: Shumar, Stephanie A., Fagone, Paolo, Alfonso-Pecchio, Adolfo, Gray, John T., Rehg, Jerold E., Jackowski, Suzanne, Leonardi, Roberta
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2015
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4460045/
https://ncbi.nlm.nih.gov/pubmed/26052948
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0130013
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