Ascorbic acid regulates osterix expression in osteoblasts by activation of prolyl hydroxylase and ubiquitination-mediated proteosomal degradation pathway

Mouse genetic studies reveal that ascorbic acid (AA) is essential for osteoblast (OB) differentiation and that osterix (Osx) was a key downstream target of AA action in OBs. To determine the molecular pathways for AA regulation of Osx expression, we evaluated if AA regulates Osx expression by regula...

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Bibliographic Details
Published in:Physiol Genomics
Main Authors: Xing, Weirong, Pourteymoor, Sheila, Mohan, Subburaman
Format: Artigo
Language:Inglês
Published: American Physiological Society 2011
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Research Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4459927/
https://ncbi.nlm.nih.gov/pubmed/21467157
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/physiolgenomics.00229.2010
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