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Type I interferon signaling contributes to the bias that Toll-like receptor 4 exhibits for signaling mediated by the adaptor protein TRIF

Signaling by Toll-like receptor 4 (TLR4) is mediated by either of two adaptor proteins: myeloid differentiation marker 88 (MyD88) or Toll–interleukin-1 (IL-1) receptor (TIR) domain–containing adaptor inducing interferon-β (TRIF). Whereas MyD88-mediated signaling leads to proinflammatory responses, T...

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Detalhes bibliográficos
Publicado no:Sci Signal
Main Authors: Kolb, Joseph P., Casella, Carolyn R., SenGupta, Shuvasree, Chilton, Paula M., Mitchell, Thomas C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4459894/
https://ncbi.nlm.nih.gov/pubmed/25389373
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.2005442
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