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Myeloid expression of Adenosine A(2A) receptor suppresses T and NK cell responses in the solid tumor microenvironment
High concentrations of adenosine in tumor microenvironments inhibit anti-tumor cytotoxic lymphocyte responses. Although T cells express inhibitory adenosine A2A receptors (A2ARs) that suppress their activation and inhibit immune killing of tumors, a role for myeloid-cell A2ARs in suppressing the imm...
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| Udgivet i: | Cancer Res |
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| Main Authors: | , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2014
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4459782/ https://ncbi.nlm.nih.gov/pubmed/25377469 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-13-3583 |
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