GRK2-Mediated Inhibition of Adrenergic and Dopaminergic Signaling in Right Ventricular Hypertrophy: Therapeutic Implications in Pulmonary Hypertension

BACKGROUND: The cause and consequences of impaired adrenergic signaling in right ventricular failure/hypertrophy (RVH) are poorly understood. We hypothesized that G protein–coupled receptor kinase-2 (GRK2)–mediated uncoupling of β-adrenergic receptor signaling impairs inotropic reserve. The implicat...

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Pubblicato in:Circulation
Autori principali: Piao, Lin, Fang, Yong-Hu, Parikh, Kishan S., Ryan, John J., D’Souza, Karen M., Theccanat, Tiju, Toth, Peter T., Pogoriler, Jennifer, Paul, Jonathan, Blaxall, Burns C., Akhter, Shahab A., Archer, Stephen L.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2012
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4459732/
https://ncbi.nlm.nih.gov/pubmed/23124027
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.112.109868
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