GRK2-Mediated Inhibition of Adrenergic and Dopaminergic Signaling in Right Ventricular Hypertrophy: Therapeutic Implications in Pulmonary Hypertension

BACKGROUND: The cause and consequences of impaired adrenergic signaling in right ventricular failure/hypertrophy (RVH) are poorly understood. We hypothesized that G protein–coupled receptor kinase-2 (GRK2)–mediated uncoupling of β-adrenergic receptor signaling impairs inotropic reserve. The implicat...

Cijeli opis

Spremljeno u:
Bibliografski detalji
Izdano u:Circulation
Glavni autori: Piao, Lin, Fang, Yong-Hu, Parikh, Kishan S., Ryan, John J., D’Souza, Karen M., Theccanat, Tiju, Toth, Peter T., Pogoriler, Jennifer, Paul, Jonathan, Blaxall, Burns C., Akhter, Shahab A., Archer, Stephen L.
Format: Artigo
Jezik:Inglês
Izdano: 2012
Teme:
Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4459732/
https://ncbi.nlm.nih.gov/pubmed/23124027
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.112.109868
Oznake: Dodaj oznaku
Bez oznaka, Budi prvi tko označuje ovaj zapis!

Similar Items