Uncoupling of Myocardial β-Adrenergic Receptor Signaling During Coronary Artery Bypass Grafting: The Role of GRK2

BACKGROUND: Cardiopulmonary bypass (CPB) and cardioplegic arrest during cardiac surgery leads to desensitization of myocardial β-adrenergic receptors (β-ARs). Impaired signaling through this pathway can have a detrimental effect on ventricular function and increased need for inotropic support. The m...

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Main Authors: Bulcao, Christian F., Pandalai, Prakash K., D’Souza, Karen M., Merrill, Walter H., Akhter, Shahab A.
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2008
Ábhair:
Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2613564/
https://ncbi.nlm.nih.gov/pubmed/18805158
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.athoracsur.2008.05.042
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