Modification of sphingolipid metabolism by tamoxifen and N-desmethyltamoxifen in acute myelogenous leukemia – Impact on enzyme activity and response to cytotoxics

The triphenylethylene antiestrogen, tamoxifen, can be an effective inhibitor of sphingolipid metabolism. This off-target activity makes tamoxifen an interesting ancillary for boosting the apoptosis-inducing properties of ceramide, a sphingolipid with valuable tumor censoring activity. Here we show f...

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Publicado en:Biochim Biophys Acta
Autores principales: Morad, Samy A. F., Tan, Su-Fern, Feith, David J., Kester, Mark, Claxton, David F., Loughran, Thomas P., Barth, Brian M., Fox, Todd E., Cabot, Myles C.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2015
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4459585/
https://ncbi.nlm.nih.gov/pubmed/25769964
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbalip.2015.03.001
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