Impact of CRFR1 Ablation on Amyloid-β Production and Accumulation in a Mouse Model of Alzheimer’s Disease

Stress exposure and the corticotropin-releasing factor (CRF) system have been implicated as mechanistically involved in both Alzheimer’s disease (AD) and associated rodent models. In particular, the major stress receptor, CRF receptor type 1 (CRFR1), modulates cellular activity in many AD-relevant b...

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Vydáno v:J Alzheimers Dis
Hlavní autoři: Campbell, Shannon N., Zhang, Cheng, Roe, Allyson D., Lee, Nickey, Lao, Kathleen U., Monte, Louise, Donohue, Michael C., Rissman, Robert A.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2015
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4459491/
https://ncbi.nlm.nih.gov/pubmed/25697705
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3233/JAD-142844
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