Infection of ectocervical tissue and universal targeting of T-cells mediated by primary non-macrophage-tropic and highly macrophage-tropic HIV-1 R5 envelopes

BACKGROUND: HIV-1 variants carrying non-macrophage-tropic HIV-1 R5 envelopes (Envs) are predominantly transmitted and persist in immune tissue even in AIDS patients who have highly macrophage-tropic variants in the brain. Non-macrophage-tropic R5 Envs require high levels of CD4 for infection contras...

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Publicado en:Retrovirology
Autores principales: Peters, Paul J, Gonzalez-Perez, Maria Paz, Musich, Thomas, Moore Simas, Tiffany A, Lin, Rongheng, Morse, Abraham N, Shattock, Robin J, Derdeyn, Cynthia A, Clapham, Paul R
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2015
Materias:
Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4459458/
https://ncbi.nlm.nih.gov/pubmed/26055104
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12977-015-0176-2
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