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The frequency of naïve and early-activated hapten-specific B cell subsets dictates the efficacy of a therapeutic vaccine against prescription opioid abuse

Translation of therapeutic vaccines for addiction, cancer or other chronic non-communicable diseases has been slow because only a small subset of immunized subjects achieved effective antibody levels. We hypothesize that individual variability in the number of naïve and early-activated hapten-specif...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Immunol
Prif Awduron: Laudenbach, Megan, Baruffaldi, Federico, Vervacke, Jeffrey S, Distefano, Mark D, Titcombe, Philip J, Mueller, Daniel L, Tubo, Noah J, Griffith, Thomas S, Pravetoni, Marco
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2015
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4458396/
https://ncbi.nlm.nih.gov/pubmed/25972483
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1500385
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