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The frequency of early-activated hapten-specific B cell subsets predicts the efficacy of vaccines for nicotine dependence
Therapeutic vaccines for nicotine addiction show pre-clinical efficacy. Yet, clinical evaluation of the first-generation nicotine vaccines did not meet expectations because only a subset of immunized subjects achieved effective serum antibody levels. Recent studies suggest that vaccine design affect...
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| Publicado no: | Vaccine |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4644437/ https://ncbi.nlm.nih.gov/pubmed/26409811 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.vaccine.2015.09.015 |
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