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The frequency of early-activated hapten-specific B cell subsets predicts the efficacy of vaccines for nicotine dependence

Therapeutic vaccines for nicotine addiction show pre-clinical efficacy. Yet, clinical evaluation of the first-generation nicotine vaccines did not meet expectations because only a subset of immunized subjects achieved effective serum antibody levels. Recent studies suggest that vaccine design affect...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Vaccine
Prif Awduron: Laudenbach, M, Tucker, AM, Runyon, SP, Carroll, FI, Pravetoni, M
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2015
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4644437/
https://ncbi.nlm.nih.gov/pubmed/26409811
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.vaccine.2015.09.015
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