A Genome-Wide Aberrant RNA Splicing in Patients with Acute Myeloid Leukemia Identifies Novel Potential Disease Markers and Therapeutic Targets

PURPOSE: Despite new treatments, acute myeloid leukemia (AML) remains an incurable disease. More effective drug design requires an expanded view of the molecular complexity that underlies AML. Alternative splicing of RNA is used by normal cells to generate protein diversity. Growing evidence indicat...

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Udgivet i:Clin Cancer Res
Main Authors: Adamia, Sophia, Haibe-Kains, Benjamin, Pilarski, Patrick M., Bar-Natan, Michal, Pevzner, Samuel, Avet-Loiseau, Herve, Lode, Laurence, Verselis, Sigitas, Fox, Edward A., Burke, John, Galinsky, Ilene, Dagogo-Jack, Ibiayi, Wadleigh, Martha, Steensma, David P., Motyckova, Gabriela, Deangelo, Daniel J., Quackenbush, John, Stone, Richard, Griffin, James D.
Format: Artigo
Sprog:Inglês
Udgivet: 2013
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4458245/
https://ncbi.nlm.nih.gov/pubmed/24284058
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-13-0956
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