A non-canonical function of Gβ as a subunit of E3 ligase in targeting GRK2 ubiquitylation

G protein-coupled receptors (GPCRs) comprise the largest family of cell-surface receptors, regulate a wide range of physiological processes, and are the major targets of pharmaceutical drugs. Canonical signaling from GPCRs is relayed to intracellular effector proteins by trimeric G proteins, compose...

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Detalhes bibliográficos
Publicado no:Mol Cell
Main Authors: Zha, Zhengyu, Han, Xiaoran, Smith, Matthew D., Liu, Yang, Giguère, Patrick M., Kopanja, Dragana, Raychaudhuri, Pradip, Siderovski, David P., Guan, Kun-Liang, Lei, Qun-Ying, Xiong, Yue
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4458238/
https://ncbi.nlm.nih.gov/pubmed/25982117
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2015.04.017
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