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Hypertension-associated C825T polymorphism impairs the function of Gβ3 to target GRK2 ubiquitination
Population-based and case–control studies in different ethnicities have linked a polymorphism, C825T, in exon 10 of GNB3 gene to hypertension and several additional diseases. The 825T allele is associated with alternative splicing and results in a shortened Gβ3 protein, referred to as Gβ3s, which lo...
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| Gepubliceerd in: | Cell Discov |
|---|---|
| Hoofdauteurs: | , , , , , |
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
Nature Publishing Group
2016
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4849471/ https://ncbi.nlm.nih.gov/pubmed/27462452 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/celldisc.2016.5 |
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