CXCR4 Blockade Attenuates Hyperoxia Induced Lung Injury in Neonatal Rats

BACKGROUND: Lung inflammation is a key factor in the pathogenesis of bronchopulmonary dysplasia (BPD). Stromal derived factor-1 (SDF-1) and its receptor chemokine receptor 4 (CXCR4) modulate the inflammatory response. Whether antagonism of CXCR4 will alleviate lung inflammation in neonatal hyperoxia...

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Pubblicato in:Neonatology
Autori principali: Drummond, Shelley, Ramachandran, Shalini, Torres, Eneida, Huang, Jian, Hehre, Dorothy, Suguihara, Cleide, Young, Karen C.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2015
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4458217/
https://ncbi.nlm.nih.gov/pubmed/25825119
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1159/000371835
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