An Apela RNA-Containing Negative Feedback Loop Regulates p53-Mediated Apoptosis in Embryonic Stem Cells

Maintaining genomic integrity is of paramount importance to embryonic stem cells (ESCs), as mutations are readily propagated to daughter cells. ESCs display hypersensitivity to DNA damage-induced apoptosis (DIA) to prevent such propagation, although the molecular mechanisms underlying this apoptotic...

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Udgivet i:Cell Stem Cell
Main Authors: Li, Mangmang, Gou, Hongfeng, Tripathi, Brajendra K., Huang, Jing, Jiang, Shunlin, Dubois, Wendy, Waybright, Tim, Lei, Ming, Shi, Jianxin, Zhou, Ming
Format: Artigo
Sprog:Inglês
Udgivet: 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4458197/
https://ncbi.nlm.nih.gov/pubmed/25936916
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2015.04.002
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