Effect of Cytochrome b5 Content on the Activity of Polymorphic CYP1A2, 2B6, and 2E1 in Human Liver Microsomes

Human cytochrome b5 (Cyt b5) plays important roles in cytochrome P450 (CYP)-mediated drug metabolism. However, the expression level of Cyt b5 in normal human liver remains largely unknown. The effect of Cyt b5 on overall CYP activity in human liver microsomes (HLM) has rarely been reported and the r...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:PLoS One
Main Authors: Zhang, Haifeng, Gao, Na, Liu, Tingting, Fang, Yan, Qi, Bing, Wen, Qiang, Zhou, Jun, Jia, Linjing, Qiao, Hailing
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2015
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4457846/
https://ncbi.nlm.nih.gov/pubmed/26046844
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0128547
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