Effect of Cytochrome b5 Content on the Activity of Polymorphic CYP1A2, 2B6, and 2E1 in Human Liver Microsomes

Human cytochrome b5 (Cyt b5) plays important roles in cytochrome P450 (CYP)-mediated drug metabolism. However, the expression level of Cyt b5 in normal human liver remains largely unknown. The effect of Cyt b5 on overall CYP activity in human liver microsomes (HLM) has rarely been reported and the r...

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Pubblicato in:PLoS One
Autori principali: Zhang, Haifeng, Gao, Na, Liu, Tingting, Fang, Yan, Qi, Bing, Wen, Qiang, Zhou, Jun, Jia, Linjing, Qiao, Hailing
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2015
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4457846/
https://ncbi.nlm.nih.gov/pubmed/26046844
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0128547
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