Glucose-Dependent Insulin Secretion in Pancreatic β-Cell Islets from Male Rats Requires Ca(2+) Release via ROS-Stimulated Ryanodine Receptors

Glucose-stimulated insulin secretion (GSIS) from pancreatic β-cells requires an increase in intracellular free Ca(2+) concentration ([Ca(2+)]). Glucose uptake into β-cells promotes Ca(2+) influx and reactive oxygen species (ROS) generation. In other cell types, Ca(2+) and ROS jointly induce Ca(2+) r...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Llanos, Paola, Contreras-Ferrat, Ariel, Barrientos, Genaro, Valencia, Marco, Mears, David, Hidalgo, Cecilia
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4457734/
https://ncbi.nlm.nih.gov/pubmed/26046640
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0129238
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