Effects of High Fat Feeding and Diabetes on Regression of Atherosclerosis Induced by Low-Density Lipoprotein Receptor Gene Therapy in LDL Receptor-Deficient Mice

We tested whether a high fat diet (HFD) containing the inflammatory dietary fatty acid palmitate or insulin deficient diabetes altered the remodeling of atherosclerotic plaques in LDL receptor knockout (Ldlr(-/-)) mice. Cholesterol reduction was achieved by using a helper-dependent adenovirus (HDAd)...

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Pubblicato in:PLoS One
Autori principali: Willecke, Florian, Yuan, Chujun, Oka, Kazuhiro, Chan, Lawrence, Hu, Yunying, Barnhart, Shelley, Bornfeldt, Karin E., Goldberg, Ira J., Fisher, Edward A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2015
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4457481/
https://ncbi.nlm.nih.gov/pubmed/26046657
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0128996
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