Structure–activity studies in the development of a hydrazone based inhibitor of adipose-triglyceride lipase (ATGL)

Adipose triglyceride lipase (ATGL) catalyzes the degradation of cellular triacylglycerol stores and strongly determines the concentration of circulating fatty acids (FAs). High serum FA levels are causally linked to the development of insulin resistance and impaired glucose tolerance, which eventual...

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Bibliographic Details
Published in:Bioorg Med Chem
Main Authors: Mayer, Nicole, Schweiger, Martina, Melcher, Michaela-Christina, Fledelius, Christian, Zechner, Rudolf, Zimmermann, Robert, Breinbauer, Rolf
Format: Artigo
Language:Inglês
Published: Elsevier Science 2015
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4457358/
https://ncbi.nlm.nih.gov/pubmed/25778769
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2015.02.051
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