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A structural rearrangement of the Na(+)/K(+)-ATPase traps ouabain within the external ion permeation pathway

Using the energy of ATP hydrolysis, the Na(+)/K(+)-ATPase is able to transport across the cell membrane Na(+) and K(+) against their electrochemical gradients. The enzyme is strongly inhibited by ouabain and its derivatives, some that are therapeutically used for patients with heart failure (cardiot...

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Podrobná bibliografie
Vydáno v:J Mol Biol
Hlavní autoři: Sánchez-Rodríguez, Jorge E., Khalili-Araghi, Fatemeh, Miranda, Pablo, Roux, Benoît, Holmgren, Miguel, Bezanilla, Francisco
Médium: Artigo
Jazyk:Inglês
Vydáno: 2015
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4457281/
https://ncbi.nlm.nih.gov/pubmed/25637661
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2015.01.011
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