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A structural rearrangement of the Na(+)/K(+)-ATPase traps ouabain within the external ion permeation pathway

Using the energy of ATP hydrolysis, the Na(+)/K(+)-ATPase is able to transport across the cell membrane Na(+) and K(+) against their electrochemical gradients. The enzyme is strongly inhibited by ouabain and its derivatives, some that are therapeutically used for patients with heart failure (cardiot...

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Bibliographische Detailangaben
Veröffentlicht in:J Mol Biol
Hauptverfasser: Sánchez-Rodríguez, Jorge E., Khalili-Araghi, Fatemeh, Miranda, Pablo, Roux, Benoît, Holmgren, Miguel, Bezanilla, Francisco
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4457281/
https://ncbi.nlm.nih.gov/pubmed/25637661
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2015.01.011
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