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On the Importance of Atomic Fluctuations, Protein Flexibility, and Solvent in Ion Permeation

Proteins, including ion channels, often are described in terms of some average structure and pictured as rigid entities immersed in a featureless solvent continuum. This simplified view, which provides for a convenient representation of the protein's overall structure, incurs the risk of deemph...

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Detalhes bibliográficos
Main Authors: Allen, Toby W., Andersen, O.S., Roux, Benoit
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2004
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2234034/
https://ncbi.nlm.nih.gov/pubmed/15572347
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.200409111
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