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A structural rearrangement of the Na(+)/K(+)-ATPase traps ouabain within the external ion permeation pathway
Using the energy of ATP hydrolysis, the Na(+)/K(+)-ATPase is able to transport across the cell membrane Na(+) and K(+) against their electrochemical gradients. The enzyme is strongly inhibited by ouabain and its derivatives, some that are therapeutically used for patients with heart failure (cardiot...
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| Publié dans: | J Mol Biol |
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| Auteurs principaux: | , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2015
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4457281/ https://ncbi.nlm.nih.gov/pubmed/25637661 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2015.01.011 |
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