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A minimally invasive, lentiviral based method for the rapid and sustained genetic manipulation of renal tubules

The accelerated discovery of disease-related genes emerging from genomic studies has strained the capacity of traditional genetically engineered mouse models (GEMMs) to provide in-vivo validation. Direct, somatic, genetic engineering approaches allow for accelerated and flexible genetic manipulation...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Espana-Agusti, Judit, Tuveson, David A., Adams, David J., Matakidou, Athena
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4457145/
https://ncbi.nlm.nih.gov/pubmed/26046460
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep11061
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