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Ten modifiers of BRCA1 penetrance validated in a Norwegian series

BACKGROUND: Common genetic variants have been shown to modify BRCA1 penetrance. The aim of this study was to validate these reports in a special cohort of Norwegian BRCA1 mutation carriers that were selected for their extreme age of onset of disease. METHODS: The ten variants rs13387042, rs3803662,...

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Bibliografski detalji
Izdano u:Hered Cancer Clin Pract
Glavni autori: Heramb, Cecilie, Ekstrøm, Per Olaf, Tharmaratnam, Kukatharmini, Hovig, Eivind, Møller, Pål, Mæhle, Lovise
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2015
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4456774/
https://ncbi.nlm.nih.gov/pubmed/26052370
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13053-015-0035-0
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