Specificity of the mutator caused by deletion of the yeast structural gene (APN1) for the major apurinic endonuclease.
The loss of bases from cellular DNA occurs via both spontaneous and mutagen-induced reactions. The resulting apurinic/apyrimidinic (AP) sites are cytotoxic and mutagenic but are counteracted by repair initiated by AP endonucleases. Previously, in vitro and bacterial transfection studies suggested th...
Shranjeno v:
| izdano v: | Proc Natl Acad Sci U S A |
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| Principais autores: | , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
National Academy of Sciences
1994
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC44566/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7520176/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.91.17.8165 |
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