PTPROt-mediated regulation of p53/Foxm1 suppresses leukemic phenotype in a CLL mouse model

The gene encoding PTPROt is methylated and suppressed in Chronic Lymphocytc Leukemia. PTPROt exhibits in vitro tumor suppressor characteristics through the regulation of B-cell receptor signaling. Here, we generated transgenic (Tg) mice with B-cell specific expression of PTPROt. While lymphocyte dev...

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Publicado en:Leukemia
Autores principales: Motiwala, Tasneem, Kutay, Huban, Zanesi, Nicola, Frissora, Frank W., Mo, Xiaokui, Muthusamy, Natarajan, Jacob, Samson T.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2014
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4456291/
https://ncbi.nlm.nih.gov/pubmed/25482129
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/leu.2014.341
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