Notch reporter activity in breast cancer cell lines identifies a subset of cells with stem cell activity

Developmental pathways such as Notch play a pivotal role in tissue specific stem cell self-renewal as well as in tumor development. However, the role of Notch signaling in breast cancer stem cells (CSC) remains to be determined. We utilized a lentiviral Notch reporter system to identify a subset of...

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Veröffentlicht in:Mol Cancer Ther
Hauptverfasser: D’Angelo, Rosemarie C., Ouzounova, Maria, Davis, April, Choi, Daejin, Tchuenkam, Stevie M., Kim, Gwangil, Luther, Tahra, Quraishi, Ahmed A., Senbabaoglu, Yasin, Conley, Sarah J., Clouthier, Shawn G., Hassan, Khaled A., Wicha, Max S., Korkaya, Hasan
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4456218/
https://ncbi.nlm.nih.gov/pubmed/25673823
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-14-0228
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