Activation of an IL-6 Inflammatory Loop Mediates Trastuzumab Resistance in HER2 Overexpressing Breast Cancers by Expanding the Cancer Stem Cell Population

Although inactivation of the PTEN gene has been implicated in the development of resistance to the HER2 targeting antibody trastuzumab, the mechanisms mediating this resistance remain elusive. We generated trastuzumab resistant cells by knocking down PTEN expression in HER2 overexpressing breast can...

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Autori principali: Korkaya, Hasan, Kim, Gwang-il, Davis, April, Malik, Fayaz, Henry, N. Lynn, Ithimakin, Suthinee, Quraishi, Ahmed A., Tawakkol, Nader, D’Angelo, Rosemarie, Paulson, Amanda, Chung, Susan, Luther, Tahra, Paholak, Hayley S., Liu, Suling, Hassan, Khaled, Zen, Qin, Clouthier, Shawn G., Wicha, Max S.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2012
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3432419/
https://ncbi.nlm.nih.gov/pubmed/22819326
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2012.06.014
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