Replication stress is a potent driver of functional decline in ageing haematopoietic stem cells

Haematopoietic stem cells (HSCs) self-renew for life, thereby making them one of the few blood cells that truly age(1,2). Paradoxically, although HSCs numerically expand with age, their functional activity declines over time, resulting in degraded blood production and impaired engraftment following...

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Detalhes bibliográficos
Publicado no:Nature
Main Authors: Flach, Johanna, Bakker, Sietske T., Mohrin, Mary, Conroy, Pauline C., Pietras, Eric M., Reynaud, Damien, Alvarez, Silvia, Diolaiti, Morgan E., Ugarte, Fernando, Forsberg, E. Camilla, Le Beau, Michelle M., Stohr, Bradley A., Méndez, Juan, Morrison, Ciaran G., Passegué, Emmanuelle
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4456040/
https://ncbi.nlm.nih.gov/pubmed/25079315
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature13619
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