Replication stress is a potent driver of functional decline in ageing haematopoietic stem cells

Haematopoietic stem cells (HSCs) self-renew for life, thereby making them one of the few blood cells that truly age(1,2). Paradoxically, although HSCs numerically expand with age, their functional activity declines over time, resulting in degraded blood production and impaired engraftment following...

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Publicat a:Nature
Autors principals: Flach, Johanna, Bakker, Sietske T., Mohrin, Mary, Conroy, Pauline C., Pietras, Eric M., Reynaud, Damien, Alvarez, Silvia, Diolaiti, Morgan E., Ugarte, Fernando, Forsberg, E. Camilla, Le Beau, Michelle M., Stohr, Bradley A., Méndez, Juan, Morrison, Ciaran G., Passegué, Emmanuelle
Format: Artigo
Idioma:Inglês
Publicat: 2014
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4456040/
https://ncbi.nlm.nih.gov/pubmed/25079315
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature13619
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