Replication stress is a potent driver of functional decline in ageing haematopoietic stem cells

Haematopoietic stem cells (HSCs) self-renew for life, thereby making them one of the few blood cells that truly age(1,2). Paradoxically, although HSCs numerically expand with age, their functional activity declines over time, resulting in degraded blood production and impaired engraftment following...

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發表在:Nature
Main Authors: Flach, Johanna, Bakker, Sietske T., Mohrin, Mary, Conroy, Pauline C., Pietras, Eric M., Reynaud, Damien, Alvarez, Silvia, Diolaiti, Morgan E., Ugarte, Fernando, Forsberg, E. Camilla, Le Beau, Michelle M., Stohr, Bradley A., Méndez, Juan, Morrison, Ciaran G., Passegué, Emmanuelle
格式: Artigo
語言:Inglês
出版: 2014
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4456040/
https://ncbi.nlm.nih.gov/pubmed/25079315
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature13619
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