Hematopoietic stem cell quiescence promotes error prone DNA repair and mutagenesis

Most adult stem cells, including hematopoietic stem cells (HSCs), are maintained in a quiescent or resting state in vivo. Quiescence is widely considered to be an essential protective mechanism for stem cells that minimizes endogenous stress caused by cellular respiration and DNA replication. Here,...

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Hlavní autoři: Mohrin, Mary, Bourke, Emer, Alexander, David, Warr, Matthew R., Barry-Holson, Keegan, Le Beau, Michelle M., Morrison, Ciaran G., Passegué, Emmanuelle
Médium: Artigo
Jazyk:Inglês
Vydáno: 2010
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2924905/
https://ncbi.nlm.nih.gov/pubmed/20619762
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2010.06.014
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