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Hematopoietic stem cell quiescence promotes error prone DNA repair and mutagenesis
Most adult stem cells, including hematopoietic stem cells (HSCs), are maintained in a quiescent or resting state in vivo. Quiescence is widely considered to be an essential protective mechanism for stem cells that minimizes endogenous stress caused by cellular respiration and DNA replication. Here,...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2924905/ https://ncbi.nlm.nih.gov/pubmed/20619762 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2010.06.014 |
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