Clonal Deletion Prunes, but does not Eliminate Self-Specific αβ CD8(+) T Lymphocytes

It has long been thought that clonal deletion efficiently removes almost all self-specific T cells from the peripheral repertoire. But here we found that self peptide-MHC specific CD8(+) T cells in the blood of healthy humans were present in frequencies similar to those specific for non-self antigen...

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Detalhes bibliográficos
Publicado no:Immunity
Main Authors: Yu, Wong, Jiang, Ning, Ebert, Peter J. R., Kidd, Brian A., Müller, Sabina, Lund, Peder J., Juang, Jeremy, Adachi, Keishi, Tse, Tiffany, Birnbaum, Michael E., Newell, Evan W., Wilson, Darrell M., Grotenbreg, Gijsbert M., Valitutti, Salvatore, Quake, Stephen R., Davis, Mark M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4455602/
https://ncbi.nlm.nih.gov/pubmed/25992863
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2015.05.001
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