Mechanisms of Thymoquinone Hepatorenal Protection in Methotrexate-Induced Toxicity in Rats

To investigate mechanisms by which thymoquinone (TQ) can prevent methotrexate- (MTX-) induced hepatorenal toxicity, TQ (10 mg/kg) was administered orally for 10 days. In independent rat groups, MTX hepatorenal toxicity was induced via 20 mg/kg i.p. at the end of day 3 of experiment, with or without...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Mediators Inflamm
Main Authors: El-Sheikh, Azza A. K., Morsy, Mohamed A., Abdalla, Ahlam M., Hamouda, Azza H., Alhaider, Ibrahim A.
Format: Artigo
Jezik:Inglês
Izdano: Hindawi Publishing Corporation 2015
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4455533/
https://ncbi.nlm.nih.gov/pubmed/26089605
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2015/859383
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