Mechanisms of Thymoquinone Hepatorenal Protection in Methotrexate-Induced Toxicity in Rats

To investigate mechanisms by which thymoquinone (TQ) can prevent methotrexate- (MTX-) induced hepatorenal toxicity, TQ (10 mg/kg) was administered orally for 10 days. In independent rat groups, MTX hepatorenal toxicity was induced via 20 mg/kg i.p. at the end of day 3 of experiment, with or without...

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Vydáno v:Mediators Inflamm
Hlavní autoři: El-Sheikh, Azza A. K., Morsy, Mohamed A., Abdalla, Ahlam M., Hamouda, Azza H., Alhaider, Ibrahim A.
Médium: Artigo
Jazyk:Inglês
Vydáno: Hindawi Publishing Corporation 2015
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4455533/
https://ncbi.nlm.nih.gov/pubmed/26089605
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2015/859383
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